![]() V D/ V T was calculated from the CO 2 production ( \(V_\) performed by the module were automatically corrected for circuit compression, as described elsewhere. ![]() After 60 min of stabilization, hemodynamics and respiratory mechanics were recorded and blood gases collected. ![]() PEEP was set targeting the best respiratory-system compliance after a PEEP-decremental recruitment maneuver. Methodsįorty-two consecutive patients with early moderate and severe ARDS were included. We sought to evaluate the relationships between dynamic variations in V D/ V T and extra-pulmonary microcirculatory blood flow detected at sublingual mucosa hypothesizing that an altered microcirculation, which is a generalized phenomenon during severe inflammatory conditions, could influence ventilation/perfusion mismatching manifested by increases in V D/ V T fraction during early stages of ARDS. Although increased dead-space ventilation ( V D/ V T) has been described in ARDS, its mechanism is not clearly understood. Ventilation/perfusion inequalities impair gas exchange in acute respiratory distress syndrome (ARDS).
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